Nature Communications (Dec 2019)
HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
- Huarong Wang,
- Han Cai,
- Xiao Wang,
- Meiling Zhang,
- Bingying Liu,
- Ziqi Chen,
- Tingting Yang,
- Junshun Fang,
- Yanhao Zhang,
- Wei Liu,
- Jun Han,
- Qirui Guo,
- Hua Zhang,
- Haibin Wang,
- Guoliang Xia,
- Chao Wang
Affiliations
- Huarong Wang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Han Cai
- Medical College of Xiamen University
- Xiao Wang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Meiling Zhang
- Shanghai Key Laboratory for Assistant Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Bingying Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Ziqi Chen
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Tingting Yang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Junshun Fang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yanhao Zhang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Wei Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Jun Han
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Qirui Guo
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Hua Zhang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Haibin Wang
- Medical College of Xiamen University
- Guoliang Xia
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Chao Wang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-019-13671-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.
