Haematologica (Feb 2008)

Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma

  • Patrick Adam,
  • Eugenia Haralambieva,
  • Martina Hartmann,
  • Zhengrong Mao,
  • German Ott,
  • Andreas Rosenwald

DOI
https://doi.org/10.3324/haematol.11950
Journal volume & issue
Vol. 93, no. 2

Abstract

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FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MAL andT1 BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.