Nature Communications (Dec 2018)
Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
- Tomohito Izumi,
- Junta Imai,
- Junpei Yamamoto,
- Yohei Kawana,
- Akira Endo,
- Hiroto Sugawara,
- Masato Kohata,
- Yoichiro Asai,
- Kei Takahashi,
- Shinjiro Kodama,
- Keizo Kaneko,
- Junhong Gao,
- Kenji Uno,
- Shojiro Sawada,
- Vladimir V. Kalinichenko,
- Yasushi Ishigaki,
- Tetsuya Yamada,
- Hideki Katagiri
Affiliations
- Tomohito Izumi
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Junta Imai
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Junpei Yamamoto
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Yohei Kawana
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Akira Endo
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Hiroto Sugawara
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Masato Kohata
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Yoichiro Asai
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Kei Takahashi
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Shinjiro Kodama
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Keizo Kaneko
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Junhong Gao
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Kenji Uno
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Shojiro Sawada
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Vladimir V. Kalinichenko
- Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center
- Yasushi Ishigaki
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Tetsuya Yamada
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Hideki Katagiri
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07747-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activation and promotion of overall survival.
