Lycocasine A, a <i>Lycopodium</i> Alkaloid from <i>Lycopodiastrum casuarinoides</i> and Its Acid-Sensing Ion Channel 1a Inhibitory Activity
Shuai Jiang,
Wen-Yan Li,
Bei-Bei Gao,
Qin-Shi Zhao
Affiliations
Shuai Jiang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Wen-Yan Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Bei-Bei Gao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Qin-Shi Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
A novel Lycopodium alkaloid, lycocasine A (1), and seven known Lycopodium alkaloids (2–8), were isolated from Lycopodiastrum casuarinoides. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis. Compound 1 features an unprecedented 5/6/6 tricyclic skeleton, highlighted by a 5-aza-tricyclic[6,3,1,02,6]dodecane motif. In bioactivity assays, compound 1 demonstrated weak inhibitory activity against acid-sensing ion channel 1a.
