Nature Communications (Mar 2020)
Differential DNA methylation of vocal and facial anatomy genes in modern humans
- David Gokhman,
- Malka Nissim-Rafinia,
- Lily Agranat-Tamir,
- Genevieve Housman,
- Raquel García-Pérez,
- Esther Lizano,
- Olivia Cheronet,
- Swapan Mallick,
- Maria A. Nieves-Colón,
- Heng Li,
- Songül Alpaslan-Roodenberg,
- Mario Novak,
- Hongcang Gu,
- Jason M. Osinski,
- Manuel Ferrando-Bernal,
- Pere Gelabert,
- Iddi Lipende,
- Deus Mjungu,
- Ivanela Kondova,
- Ronald Bontrop,
- Ottmar Kullmer,
- Gerhard Weber,
- Tal Shahar,
- Mona Dvir-Ginzberg,
- Marina Faerman,
- Ellen E. Quillen,
- Alexander Meissner,
- Yonatan Lahav,
- Leonid Kandel,
- Meir Liebergall,
- María E. Prada,
- Julio M. Vidal,
- Richard M. Gronostajski,
- Anne C. Stone,
- Benjamin Yakir,
- Carles Lalueza-Fox,
- Ron Pinhasi,
- David Reich,
- Tomas Marques-Bonet,
- Eran Meshorer,
- Liran Carmel
Affiliations
- David Gokhman
- Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
- Malka Nissim-Rafinia
- Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
- Lily Agranat-Tamir
- Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
- Genevieve Housman
- School of Human Evolution and Social Change, Arizona State University
- Raquel García-Pérez
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Esther Lizano
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Olivia Cheronet
- Department of Evolutionary Anthropology, University of Vienna
- Swapan Mallick
- Broad Institute
- Maria A. Nieves-Colón
- School of Human Evolution and Social Change, Arizona State University
- Heng Li
- Broad Institute
- Songül Alpaslan-Roodenberg
- Department of Genetics, Harvard Medical School
- Mario Novak
- Institute for Anthropological Research
- Hongcang Gu
- Broad Institute
- Jason M. Osinski
- Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
- Manuel Ferrando-Bernal
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Pere Gelabert
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Iddi Lipende
- Gombe Stream Research Center, Jane Goodall Institute
- Deus Mjungu
- Gombe Stream Research Center, Jane Goodall Institute
- Ivanela Kondova
- Biomedical Primate Research Centre (BPRC)
- Ronald Bontrop
- Biomedical Primate Research Centre (BPRC)
- Ottmar Kullmer
- Department of Palaeoanthropology and Messel Research, Senckenberg Center of Human Evolution and Paleoecology
- Gerhard Weber
- Department of Evolutionary Anthropology, University of Vienna
- Tal Shahar
- Department of Neurosurgery, Shaare Zedek Medical Center
- Mona Dvir-Ginzberg
- Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University of Jerusalem
- Marina Faerman
- Laboratory of Bioanthropology and Ancient DNA, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem
- Ellen E. Quillen
- Department of Genetics, Texas Biomedical Research Institute
- Alexander Meissner
- Broad Institute
- Yonatan Lahav
- Otolaryngology - Head & Neck Surgery Department, Laryngeal Surgery Unit, Kaplan Medical Center
- Leonid Kandel
- Orthopaedic Department, Hadassah – Hebrew University Medical Center
- Meir Liebergall
- Orthopaedic Department, Hadassah – Hebrew University Medical Center
- María E. Prada
- I.E.S.O. ‘Los Salados’. Junta de Castilla y León
- Julio M. Vidal
- Junta de Castilla y León, Servicio de Cultura de León
- Richard M. Gronostajski
- Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
- Anne C. Stone
- School of Human Evolution and Social Change, Arizona State University
- Benjamin Yakir
- Department of Statistics, The Hebrew University of Jerusalem
- Carles Lalueza-Fox
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Ron Pinhasi
- Department of Evolutionary Anthropology, University of Vienna
- David Reich
- Broad Institute
- Tomas Marques-Bonet
- Institute of Evolutionary Biology (UPF-CSIC), PRBB
- Eran Meshorer
- Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
- Liran Carmel
- Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
- DOI
- https://doi.org/10.1038/s41467-020-15020-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
How traits specific to modern humans have evolved is difficult to study. Here, Gokhman et al. compare measured and reconstructed DNA methylation maps of present-day humans, archaic humans and chimpanzees and find that genes that affect vocal tract and facial anatomy show methylation changes between archaic and modern humans.
