Molecular Hybrids of Pyazolo[3,4-<i>b</i>]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies
Narasimha Rao Bandaru,
Parameshwar Makam,
Parameswari Akshinthala,
Naresh Kumar Katari,
Venkanna Banoth,
Balakrishna Kolli,
Rambabu Gundla
Affiliations
Narasimha Rao Bandaru
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University Hyderabad, Rudraram 502329, India
Parameshwar Makam
Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, Chandanwari, Premnagar, Dehradun 248007, India
Parameswari Akshinthala
Department of Science and Humanities, MLR Institute of Technology, Dundigal, Medchal, Hyderabad, Rudraram 500043, India
Naresh Kumar Katari
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University Hyderabad, Rudraram 502329, India
Venkanna Banoth
Department of Biotechnology, University Post Graduate College of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Rudraram 500085, India
Balakrishna Kolli
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University Hyderabad, Rudraram 502329, India
Rambabu Gundla
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University Hyderabad, Rudraram 502329, India
Antimicrobial resistance is on the rise, and there aren’t enough new treatments to combat it. This might send the modern world back to the pre-antibiotic age. The molecular hybrids of pyrazolo[3,4-b]pyridine and triazole have been designed, synthesized, and analyzed for their drug-like molecule nature and in vitro analyses for their inhibition potentials against S. aureus and K. pneumoniae. The compounds 24 and 27 have been identified as the high potential molecules in this series based on in vitro experiments. Compound 24 has zone of inhibition values of 15 ± 0.82 mm and 14 ± 0.7 mm, whilst compound 27 has zone of inhibition values of 18 ± 0.95 mm and 16 ± 0.82 mm against S. aureus and K. pneumoniae, respectively. MIC and MIB values for compounds 24 and 27 against S. aureus and K. pneumoniae are 0.25 and 0.5, respectively.
