MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Yosuke Komata; Akinori Kanai; Takahiro Maeda; Toshiya Inaba; Akihiko Yokoyama

doi:10.1038/s41467-023-37712-5

Nature Communications (Apr 2023)

MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Yosuke Komata,
Akinori Kanai,
Takahiro Maeda,
Toshiya Inaba,
Akihiko Yokoyama

Affiliations

Yosuke Komata: Tsuruoka Metabolomics Laboratory, National Cancer Center
Akinori Kanai: Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo
Takahiro Maeda: Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences
Toshiya Inaba: Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University
Akihiko Yokoyama: Tsuruoka Metabolomics Laboratory, National Cancer Center

DOI: https://doi.org/10.1038/s41467-023-37712-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF lysine acetyltransferases

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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