Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature

Abstract

Zhen Hu, Huaying Zhou Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of ChinaCorrespondence: Huaying Zhou, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China, Email [email protected]: Combination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole.Case Presentation: A patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone.Conclusion: AmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.Keywords: amphotericin B, voriconazole, fungal infection, drug interaction

Keywords

• amphotericin b ▪ voriconazole ▪ fungal infection ▪drug interaction