Prospective application of poloxamer 188 in plastic surgery: A comprehensive review

Yujia Shang; Shiou Zhu; Fangfei Nie; Yonghuan Zhen; Pengbing Ding; Dong Li; Hua Li; Yang An

Chinese Journal of Plastic and Reconstructive Surgery (Mar 2022)

Prospective application of poloxamer 188 in plastic surgery: A comprehensive review

Yujia Shang,
Shiou Zhu,
Fangfei Nie,
Yonghuan Zhen,
Pengbing Ding,
Dong Li,
Hua Li,
Yang An

Affiliations

Yujia Shang: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
Shiou Zhu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China
Fangfei Nie: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China
Yonghuan Zhen: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China
Pengbing Ding: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China
Dong Li: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Corresponding authors. Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing 100191, China.
Hua Li: Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenhe District, Shenyang 110016, Liaoning, China.
Yang An: Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Corresponding authors. Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing 100191, China.

Journal volume & issue: Vol. 4, no. 1
pp. 31 – 37

Abstract

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An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery.

Published in Chinese Journal of Plastic and Reconstructive Surgery

ISSN: 2096-6911 (Print); 2772-686X (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Medicine: Surgery
Website: https://www.keaipublishing.com/en/journals/chinese-journal-of-plastic-and-reconstructive-surgery/

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