Nature Communications (May 2018)
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
- Adriana I. Iglesias,
- Aniket Mishra,
- Veronique Vitart,
- Yelena Bykhovskaya,
- René Höhn,
- Henriët Springelkamp,
- Gabriel Cuellar-Partida,
- Puya Gharahkhani,
- Jessica N. Cooke Bailey,
- Colin E. Willoughby,
- Xiaohui Li,
- Seyhan Yazar,
- Abhishek Nag,
- Anthony P. Khawaja,
- Ozren Polašek,
- David Siscovick,
- Paul Mitchell,
- Yih Chung Tham,
- Jonathan L. Haines,
- Lisa S. Kearns,
- Caroline Hayward,
- Yuan Shi,
- Elisabeth M. van Leeuwen,
- Kent D. Taylor,
- Blue Mountains Eye Study—GWAS group,
- Pieter Bonnemaijer,
- Jerome I. Rotter,
- Nicholas G. Martin,
- Tanja Zeller,
- Richard A. Mills,
- Emmanuelle Souzeau,
- Sandra E. Staffieri,
- Jost B. Jonas,
- Irene Schmidtmann,
- Thibaud Boutin,
- Jae H. Kang,
- Sionne E. M. Lucas,
- Tien Yin Wong,
- Manfred E. Beutel,
- James F. Wilson,
- NEIGHBORHOOD Consortium,
- Wellcome Trust Case Control Consortium 2 (WTCCC2),
- André G. Uitterlinden,
- Eranga N. Vithana,
- Paul J. Foster,
- Pirro G. Hysi,
- Alex W. Hewitt,
- Chiea Chuen Khor,
- Louis R. Pasquale,
- Grant W. Montgomery,
- Caroline C. W. Klaver,
- Tin Aung,
- Norbert Pfeiffer,
- David A. Mackey,
- Christopher J. Hammond,
- Ching-Yu Cheng,
- Jamie E. Craig,
- Yaron S. Rabinowitz,
- Janey L. Wiggs,
- Kathryn P. Burdon,
- Cornelia M. van Duijn,
- Stuart MacGregor
Affiliations
- Adriana I. Iglesias
- Department of Ophthalmology, Erasmus Medical Center
- Aniket Mishra
- University of Bordeaux, Bordeaux Population Health Research Center
- Veronique Vitart
- Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh
- Yelena Bykhovskaya
- Regenerative Medicine Institute and Department of Surgery, Cedars-Sinai Medical Center
- René Höhn
- Department of Ophthalmology, University Medical Center Mainz
- Henriët Springelkamp
- Department of Ophthalmology, Erasmus Medical Center
- Gabriel Cuellar-Partida
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Puya Gharahkhani
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Jessica N. Cooke Bailey
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Colin E. Willoughby
- Biomedical Sciences Research Institute, Ulster University
- Xiaohui Li
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Seyhan Yazar
- Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh
- Abhishek Nag
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Anthony P. Khawaja
- Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine
- Ozren Polašek
- Faculty of Medicine, University of Split
- David Siscovick
- Departments of Medicine and Epidemiology and Cardiovascular Health Research Unit, University of Washington
- Paul Mitchell
- Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney
- Yih Chung Tham
- Singapore Eye Research Institute, Singapore National Eye Centre
- Jonathan L. Haines
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Lisa S. Kearns
- Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital
- Caroline Hayward
- Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh
- Yuan Shi
- Singapore Eye Research Institute, Singapore National Eye Centre
- Elisabeth M. van Leeuwen
- Department of Ophthalmology, Erasmus Medical Center
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Blue Mountains Eye Study—GWAS group
- Pieter Bonnemaijer
- Department of Ophthalmology, Erasmus Medical Center
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Nicholas G. Martin
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Tanja Zeller
- Department of General and Interventional Cardiology, University Heart Center Hamburg
- Richard A. Mills
- Department of Ophthalmology, Flinders University
- Emmanuelle Souzeau
- Department of Ophthalmology, Flinders University
- Sandra E. Staffieri
- Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital
- Jost B. Jonas
- Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg
- Irene Schmidtmann
- Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz
- Thibaud Boutin
- Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh
- Jae H. Kang
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Sionne E. M. Lucas
- Menzies Institute for Medical Research, University of Tasmania
- Tien Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- Manfred E. Beutel
- Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz
- James F. Wilson
- Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh
- NEIGHBORHOOD Consortium
- Wellcome Trust Case Control Consortium 2 (WTCCC2)
- André G. Uitterlinden
- Department of Epidemiology, Erasmus Medical Center
- Eranga N. Vithana
- Singapore Eye Research Institute, Singapore National Eye Centre
- Paul J. Foster
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
- Pirro G. Hysi
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Alex W. Hewitt
- Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital
- Chiea Chuen Khor
- Genome Institute of Singapore
- Louis R. Pasquale
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Grant W. Montgomery
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Caroline C. W. Klaver
- Department of Ophthalmology, Erasmus Medical Center
- Tin Aung
- Singapore Eye Research Institute, Singapore National Eye Centre
- Norbert Pfeiffer
- Department of Ophthalmology, University Medical Center Mainz
- David A. Mackey
- Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute
- Christopher J. Hammond
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Jamie E. Craig
- Department of Ophthalmology, Flinders University
- Yaron S. Rabinowitz
- Regenerative Medicine Institute and Department of Surgery, Cedars-Sinai Medical Center
- Janey L. Wiggs
- Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary
- Kathryn P. Burdon
- Menzies Institute for Medical Research, University of Tasmania
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus Medical Center
- Stuart MacGregor
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-03646-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.
