Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer

Abstract

Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will likely lead to novel and effective combination therapy for advanced prostate cancer.

Keywords

• atr-chk1
• combination therapy
• enzalutamide
• mcrpc