CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION
A. S. Vorobyev,
L. V. Kovalenko,
K. Yu. Nikolaev,
I. A. Urvantseva,
T. О. Simonyan,
М. I. Rudenko
Affiliations
A. S. Vorobyev
Surgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery Russian Federation
L. V. Kovalenko
Surgut State University Russian Federation
K. Yu. Nikolaev
Surgut State University; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian Federation
I. A. Urvantseva
Surgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery Russian Federation
In this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of postinfarction LV myocardial remodeling. In patients who had serum concentrations of TIMP-1 over the established cut-off value (144.0 ng/ml), the risk of post-infarction LV remodeling was 3.33 times higher than in individuals who had TIMP-1 levels lower this value. Thus, TIMP-1 is a reliable prediction biomarker of adverse left ventricular myocardial remodeling in Q-wave MI.
