E-Journal of Chemistry (Jan 2011)

Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I

  • Reda M. Abdel-Rahman,
  • Mohammad Saleh I. T. Makki,
  • Wafa A. Bawazir

DOI
https://doi.org/10.1155/2011/586063
Journal volume & issue
Vol. 8, no. 1
pp. 405 – 414

Abstract

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Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five-membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4-triazole derivatives (3-13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a-f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare with Nystatin and Nalidixic acid.