Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I

E-Journal of Chemistry. 2011;8(1):405-414 DOI 10.1155/2011/586063

 

Journal Homepage

Journal Title: E-Journal of Chemistry

ISSN: 0973-4945 (Print); 2090-9810 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Science: Chemistry

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Reda M. Abdel-Rahman (Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah-21315, Saudi Arabia)
Mohammad Saleh I. T. Makki (Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah-21315, Saudi Arabia)
Wafa A. Bawazir (Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah-21315, Saudi Arabia)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 18 weeks

 

Abstract | Full Text

Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five-membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4-triazole derivatives (3-13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a-f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare with Nystatin and Nalidixic acid.