Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival

Zhengtai Chen; Hongqiang Wu; Jianxin Yang; Baolong Li; Jian Ding; Sheng Cheng; Nageeb Bsoul; Chenxi Zhang; jiaorong li; Haixiao Liu; Damu Lin; Weiyang Gao

doi:10.1038/s42003-022-03556-w

Communications Biology (Jun 2022)

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival

Zhengtai Chen,
Hongqiang Wu,
Jianxin Yang,
Baolong Li,
Jian Ding,
Sheng Cheng,
Nageeb Bsoul,
Chenxi Zhang,
jiaorong li,
Haixiao Liu,
Damu Lin,
Weiyang Gao

Affiliations

Zhengtai Chen: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Hongqiang Wu: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Jianxin Yang: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Baolong Li: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Jian Ding: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Sheng Cheng: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Nageeb Bsoul: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Chenxi Zhang: Department of Orthopedics, The Number 6 Hospital of Ningbo
jiaorong li: Wenzhou Medical University
Haixiao Liu: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Damu Lin: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Weiyang Gao: Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University

DOI: https://doi.org/10.1038/s42003-022-03556-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Melatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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