This study aimed to identify the effect of different head positions on hand grip strength (HGS) on account of hand dominance, age, and sex in dentists. A total of 197 dental students (DS) and practitioners (DP) (81 females and 50 males were DS, 10 females and 14 males were (DP) aged 19-63 participated. HGS was measured using a dynamometer, and the head angle was determined with an inclinometer. HGS on both sides was greatest in NHP & displayed least strength in HEP. There was a significant difference in HGS measured in NHP, HFP, and HEP (p 0.05) for female DS. A significant difference was recorded between dominant and non-dominant HGS in each head position (p < 0.05). Significant differences were also found between female and male DP HGS (p < 0.05) and DS (p < 0.05), particularly at HFP and HEP. There was a significant difference noted between female DS and DP HGS, however, HGS for both dominant and non-dominant hands in DP was higher than DS in HEP (p < 0.05), while no significant difference noted for HFP and NHP. Females had the strongest grip in NHP, while males in HFP. HGS influenced by age; DP had stronger grip than DS. In a comparison between male and female DP and DS, males had stronger grip than females across all positions. Hand dominance significantly influences HGS, with the dominant having a stronger hand grip.