Антибиотики и Химиотерапия (May 2020)

ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A

  • O. V. Efremenkova,
  • N. I. Gabrielyan,
  • I. A. Malanicheva,
  • T. A. Efimenko,
  • I. G. Sumarukova,
  • A. A. Gluhova,
  • YU. V. Boykova,
  • E. A. Rogozhin,
  • A. M. Korolev,
  • V. A. Korshun,
  • I. V. Drabkina

Journal volume & issue
Vol. 62, no. 1-2
pp. 16 – 19

Abstract

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The in vitro activity of the antibiotic amikumacin A against 22 collective test strains and 24 clinical isolates of bacteria and fungi was studied. It is shown that amicoumycin A has a broad antimicrobial spectrum of activity. The minimum inhibitory concentration (MIC) of amicoumycin A against methicillin-resistant Staphylococcus aureus (MRSA) and resistant to glycopeptide antibiotics of vancomycin group (VR) test strain Leuconostoc mesenteroides of 0.06 ^g/disk were established. In the study of multidrug-resistant clinical isolates, amikumacin A exhibited activity against S.aureus, S.epidermidis, C.krusei, Cr.neoformis and Prototheca spp. strains.

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