“Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and glucose study”

Abstract

Abstract Background Chronic kidney disease(CKD) has been proposed as a risk factor for cardiovascular disease (CVD). There is conflicting evidence among community based studies regarding the association between CKD and CVD. Furthermore, in order to assess the possible interaction between CKD and BMI, we also examined the association between CKD and CVD, across different BMI categories. Methods The risk of CVD events was evaluated in a large cohort of participants selected from the Tehran Lipid and Glucose Study. Participants(mean age, 47.4 years) free of previous CVD were followed up for 9.1 years. GFR ml/min per 1.73 m2 was estimated using the MDRD formula. Results Of the 6,209 participants, 22.2%(1381) had CKD with eGFR ml/min per 1.73 m2 P = 0.2). Conclusion CKD was not an independent risk factor for CVD events in a community-based study in a Tehranian population and the higher prevalence of CVD in subjects with mild to moderate renal insufficiency might be due to the co-occurrence of traditional CVD risk factors in this group.

Keywords

• Chronic kidney disease
• Cardiovascular disease
• Body mass index
• Glomerular filtration rate
• General population