Preparation and characterization of pH sensitive hydrogel for sustained release of metoclopramide

Abstract

Objective: The aim of present research work was focus on preparation of PVA/SA hydrogels for Metoclopramide HCl drug release and investigates swelling and release study. Method: Chemical cross-linking method was used for the preparation of PVA/SA hydrogels in which glutaraldehyde was used as cross linker. By changing the concentration of polymers and cross linker different samples were prepared. Results: Characterization was done by FTIR, Sol gel analysis, swelling studies. Release studied was carried out at in pH (1.2-7.5) of phosphate buffer and its absorbance was determined by using UV spectrophotometer. Zero order, 1st order, Higuchi and Korsmeyer- Peppas model were used to evaluate the drug release. Conclusion: It was concluded from the study that hydrogel could be one of the best approaches to enhanced sustained release of metoclopramide.

Keywords

• Hydrogels
• Cross-linking
• Sodium alginate
• Polyvinyl alcohol
• FTIR