eLife (Dec 2017)
The Human Cell Atlas
- Aviv Regev,
- Sarah A Teichmann,
- Eric S Lander,
- Ido Amit,
- Christophe Benoist,
- Ewan Birney,
- Bernd Bodenmiller,
- Peter Campbell,
- Piero Carninci,
- Menna Clatworthy,
- Hans Clevers,
- Bart Deplancke,
- Ian Dunham,
- James Eberwine,
- Roland Eils,
- Wolfgang Enard,
- Andrew Farmer,
- Lars Fugger,
- Berthold Göttgens,
- Nir Hacohen,
- Muzlifah Haniffa,
- Martin Hemberg,
- Seung Kim,
- Paul Klenerman,
- Arnold Kriegstein,
- Ed Lein,
- Sten Linnarsson,
- Emma Lundberg,
- Joakim Lundeberg,
- Partha Majumder,
- John C Marioni,
- Miriam Merad,
- Musa Mhlanga,
- Martijn Nawijn,
- Mihai Netea,
- Garry Nolan,
- Dana Pe'er,
- Anthony Phillipakis,
- Chris P Ponting,
- Stephen Quake,
- Wolf Reik,
- Orit Rozenblatt-Rosen,
- Joshua Sanes,
- Rahul Satija,
- Ton N Schumacher,
- Alex Shalek,
- Ehud Shapiro,
- Padmanee Sharma,
- Jay W Shin,
- Oliver Stegle,
- Michael Stratton,
- Michael J T Stubbington,
- Fabian J Theis,
- Matthias Uhlen,
- Alexander van Oudenaarden,
- Allon Wagner,
- Fiona Watt,
- Jonathan Weissman,
- Barbara Wold,
- Ramnik Xavier,
- Nir Yosef,
- Human Cell Atlas Meeting Participants
Affiliations
- Aviv Regev
- ORCiD
- Broad Institute of MIT and Harvard, Cambridge, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, United States; Howard Hughes Medical Institute, Chevy Chase, United States
- Sarah A Teichmann
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom
- Eric S Lander
- Broad Institute of MIT and Harvard, Cambridge, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, United States; Department of Systems Biology, Harvard Medical School, Boston, United States
- Ido Amit
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Christophe Benoist
- Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States
- Ewan Birney
- EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Bernd Bodenmiller
- EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland
- Peter Campbell
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom
- Piero Carninci
- ORCiD
- Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan
- Menna Clatworthy
- Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, United Kingdom
- Hans Clevers
- Hubrecht Institute, Princess Maxima Center for Pediatric Oncology and University Medical Center Utrecht, Utrecht, The Netherlands
- Bart Deplancke
- ORCiD
- Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
- Ian Dunham
- EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- James Eberwine
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
- Roland Eils
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany
- Wolfgang Enard
- ORCiD
- Department of Biology II, Ludwig Maximilian University Munich, Martinsried, Germany
- Andrew Farmer
- Takara Bio United States, Inc., Mountain View, United States
- Lars Fugger
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
- Berthold Göttgens
- ORCiD
- Department of Haematology, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
- Nir Hacohen
- Broad Institute of MIT and Harvard, Cambridge, United States; Massachusetts General Hospital Cancer Center, Boston, United States
- Muzlifah Haniffa
- ORCiD
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
- Martin Hemberg
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Seung Kim
- Departments of Developmental Biology and of Medicine, Stanford University School of Medicine, Stanford, United States
- Paul Klenerman
- Peter Medawar Building for Pathogen Research and the Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
- Arnold Kriegstein
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States
- Ed Lein
- ORCiD
- Allen Institute for Brain Science, Seattle, United States
- Sten Linnarsson
- Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
- Emma Lundberg
- Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Genetics, Stanford University, Stanford, United States
- Joakim Lundeberg
- Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden
- Partha Majumder
- National Institute of Biomedical Genomics, Kalyani, India
- John C Marioni
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
- Miriam Merad
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States
- Musa Mhlanga
- Division of Chemical, Systems & Synthetic Biology, Institute for Infectious Disease & Molecular Medicine (IDM), Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Martijn Nawijn
- Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- Mihai Netea
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
- Garry Nolan
- Department of Microbiology and Immunology, Stanford University, Stanford, United States
- Dana Pe'er
- Computational and Systems Biology Program, Sloan Kettering Institute, New York, United States
- Anthony Phillipakis
- Broad Institute of MIT and Harvard, Cambridge, United States
- Chris P Ponting
- ORCiD
- MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
- Stephen Quake
- Department of Applied Physics and Department of Bioengineering, Stanford University, Stanford, United States; Chan Zuckerberg Biohub, San Francisco, United States
- Wolf Reik
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Epigenetics Programme, The Babraham Institute, Cambridge, United Kingdom; Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
- Orit Rozenblatt-Rosen
- Broad Institute of MIT and Harvard, Cambridge, United States
- Joshua Sanes
- ORCiD
- Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States
- Rahul Satija
- ORCiD
- Department of Biology, New York University, New York, United States; New York Genome Center, New York University, New York, United States
- Ton N Schumacher
- Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
- Alex Shalek
- Broad Institute of MIT and Harvard, Cambridge, United States; Institute for Medical Engineering & Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States; Ragon Institute of MGH, MIT and Harvard, Cambridge, United States
- Ehud Shapiro
- Department of Computer Science and Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
- Padmanee Sharma
- Department of Genitourinary Medical Oncology, Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, United States
- Jay W Shin
- Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan
- Oliver Stegle
- EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Michael Stratton
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Michael J T Stubbington
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Fabian J Theis
- Institute of Computational Biology, German Research Center for Environmental Health, Helmholtz Center Munich, Neuherberg, Germany; Department of Mathematics, Technical University of Munich, Garching, Germany
- Matthias Uhlen
- Science for Life Laboratory and Department of Proteomics, KTH Royal Institute of Technology, Stockholm, Sweden; Novo Nordisk Foundation Center for Biosustainability, Danish Technical University, Lyngby, Denmark
- Alexander van Oudenaarden
- Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands
- Allon Wagner
- Department of Electrical Engineering and Computer Science and the Center for Computational Biology, University of California, Berkeley, Berkeley, United States
- Fiona Watt
- ORCiD
- Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom
- Jonathan Weissman
- ORCiD
- Howard Hughes Medical Institute, Chevy Chase, United States; Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, United States; California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, United States; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, United States
- Barbara Wold
- Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States
- Ramnik Xavier
- Broad Institute of MIT and Harvard, Cambridge, United States; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, United States; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, United States
- Nir Yosef
- ORCiD
- Ragon Institute of MGH, MIT and Harvard, Cambridge, United States; Department of Electrical Engineering and Computer Science and the Center for Computational Biology, University of California, Berkeley, Berkeley, United States
- Human Cell Atlas Meeting Participants
- DOI
- https://doi.org/10.7554/eLife.27041
- Journal volume & issue
-
Vol. 6
Abstract
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
Keywords
