Nature Communications (May 2021)
Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
Abstract
Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depression.