Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

Muhammad Shoaib; Qinming Chen; Xiangyan Shi; Nidhi Nair; Chinmayi Prasanna; Renliang Yang; David Walter; Klaus S. Frederiksen; Hjorleifur Einarsson; J. Peter Svensson; Chuan Fa Liu; Karl Ekwall; Mads Lerdrup; Lars Nordenskiöld; Claus S. Sørensen

doi:10.1038/s41467-021-25051-2

Nature Communications (Aug 2021)

Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

Muhammad Shoaib,
Qinming Chen,
Xiangyan Shi,
Nidhi Nair,
Chinmayi Prasanna,
Renliang Yang,
David Walter,
Klaus S. Frederiksen,
Hjorleifur Einarsson,
J. Peter Svensson,
Chuan Fa Liu,
Karl Ekwall,
Mads Lerdrup,
Lars Nordenskiöld,
Claus S. Sørensen

Affiliations

Muhammad Shoaib: Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen
Qinming Chen: School of Biological Sciences, Nanyang Technological University
Xiangyan Shi: School of Physical and Mathematical Sciences, Nanyang Technological University
Nidhi Nair: Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen
Chinmayi Prasanna: School of Biological Sciences, Nanyang Technological University
Renliang Yang: School of Biological Sciences, Nanyang Technological University
David Walter: Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen
Klaus S. Frederiksen: Global Drug Discovery, Novo Nordisk A/S
Hjorleifur Einarsson: Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen
J. Peter Svensson: Department of Biosciences and Nutrition, Karolinska Institute
Chuan Fa Liu: School of Biological Sciences, Nanyang Technological University
Karl Ekwall: Department of Biosciences and Nutrition, Karolinska Institute
Mads Lerdrup: Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Lars Nordenskiöld: School of Biological Sciences, Nanyang Technological University
Claus S. Sørensen: Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-021-25051-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The effect of histone H4 lysine 20 methylation (H4K20me) on chromatin accessibility are not well established. Here the authors show how H4K20 methylation regulates chromatin structure and accessibility to ensure precise transcriptional outputs through the cell cycle using genome-wide approaches, in vitro biophysical assays, and NMR.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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