Nature Communications (Jan 2019)
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
- Simon Haworth,
- Chin Yang Shapland,
- Caroline Hayward,
- Bram P. Prins,
- Janine F. Felix,
- Carolina Medina-Gomez,
- Fernando Rivadeneira,
- Carol Wang,
- Tarunveer S. Ahluwalia,
- Martine Vrijheid,
- Mònica Guxens,
- Jordi Sunyer,
- Ioanna Tachmazidou,
- Klaudia Walter,
- Valentina Iotchkova,
- Andrew Jackson,
- Louise Cleal,
- Jennifer Huffmann,
- Josine L. Min,
- Lærke Sass,
- Paul R. H. J. Timmers,
- UK10K consortium,
- George Davey Smith,
- Simon E. Fisher,
- James F. Wilson,
- Tim J. Cole,
- Dietmar Fernandez-Orth,
- Klaus Bønnelykke,
- Hans Bisgaard,
- Craig E. Pennell,
- Vincent W. V. Jaddoe,
- George Dedoussis,
- Nicholas Timpson,
- Eleftheria Zeggini,
- Veronique Vitart,
- Beate St Pourcain
Affiliations
- Simon Haworth
- MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Chin Yang Shapland
- Language and Genetics Department, Max Planck Institute for Psycholinguistics
- Caroline Hayward
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Bram P. Prins
- Wellcome Sanger Institute, Wellcome Genome Campus
- Janine F. Felix
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Carolina Medina-Gomez
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Fernando Rivadeneira
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Carol Wang
- School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
- Tarunveer S. Ahluwalia
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Martine Vrijheid
- ISGlobal
- Mònica Guxens
- ISGlobal
- Jordi Sunyer
- ISGlobal
- Ioanna Tachmazidou
- Wellcome Sanger Institute, Wellcome Genome Campus
- Klaudia Walter
- Wellcome Sanger Institute, Wellcome Genome Campus
- Valentina Iotchkova
- Wellcome Sanger Institute, Wellcome Genome Campus
- Andrew Jackson
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Louise Cleal
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Jennifer Huffmann
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Josine L. Min
- MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Lærke Sass
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Paul R. H. J. Timmers
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- UK10K consortium
- George Davey Smith
- MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Simon E. Fisher
- Language and Genetics Department, Max Planck Institute for Psycholinguistics
- James F. Wilson
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Tim J. Cole
- Faculty of Population Health Sciences, UCL Great Ormond Street Institute of Child Health
- Dietmar Fernandez-Orth
- ISGlobal
- Klaus Bønnelykke
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Hans Bisgaard
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Craig E. Pennell
- School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- George Dedoussis
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University
- Nicholas Timpson
- MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Eleftheria Zeggini
- Wellcome Sanger Institute, Wellcome Genome Campus
- Veronique Vitart
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Beate St Pourcain
- MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-018-07863-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.
