Hallmarks of peripheral nerve function in bone regeneration
Ranyang Tao,
Bobin Mi,
Yiqiang Hu,
Sien Lin,
Yuan Xiong,
Xuan Lu,
Adriana C. Panayi,
Gang Li,
Guohui Liu
Affiliations
Ranyang Tao
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Bobin Mi
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yiqiang Hu
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sien Lin
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Yuan Xiong
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xuan Lu
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Adriana C. Panayi
Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School
Gang Li
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Guohui Liu
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Abstract Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and nerves remains unclear. In this review, we outline the role of the peripheral nervous system (PNS) in bone regeneration following injury. We first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to mammals. We then present the distribution of the PNS in the skeletal system under physiological conditions, fractures, or regeneration. Furthermore, we summarize the ways in which the PNS communicates with bone-lineage cells, the vasculature, and immune cells in the bone microenvironment. Based on this comprehensive and timely review, we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral nerves. An in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration.
