Nature Communications (Jun 2021)
Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
- Anna K. Bonkhoff,
- Markus D. Schirmer,
- Martin Bretzner,
- Sungmin Hong,
- Robert W. Regenhardt,
- Mikael Brudfors,
- Kathleen L. Donahue,
- Marco J. Nardin,
- Adrian V. Dalca,
- Anne-Katrin Giese,
- Mark R. Etherton,
- Brandon L. Hancock,
- Steven J. T. Mocking,
- Elissa C. McIntosh,
- John Attia,
- Oscar R. Benavente,
- Stephen Bevan,
- John W. Cole,
- Amanda Donatti,
- Christoph J. Griessenauer,
- Laura Heitsch,
- Lukas Holmegaard,
- Katarina Jood,
- Jordi Jimenez-Conde,
- Steven J. Kittner,
- Robin Lemmens,
- Christopher R. Levi,
- Caitrin W. McDonough,
- James F. Meschia,
- Chia-Ling Phuah,
- Arndt Rolfs,
- Stefan Ropele,
- Jonathan Rosand,
- Jaume Roquer,
- Tatjana Rundek,
- Ralph L. Sacco,
- Reinhold Schmidt,
- Pankaj Sharma,
- Agnieszka Slowik,
- Martin Söderholm,
- Alessandro Sousa,
- Tara M. Stanne,
- Daniel Strbian,
- Turgut Tatlisumak,
- Vincent Thijs,
- Achala Vagal,
- Johan Wasselius,
- Daniel Woo,
- Ramin Zand,
- Patrick F. McArdle,
- Bradford B. Worrall,
- Christina Jern,
- Arne G. Lindgren,
- Jane Maguire,
- Danilo Bzdok,
- Ona Wu,
- MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium,
- Natalia S. Rost
Affiliations
- Anna K. Bonkhoff
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Markus D. Schirmer
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Martin Bretzner
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Sungmin Hong
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Robert W. Regenhardt
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Mikael Brudfors
- School of Biomedical Engineering & Imaging Sciences, King’s College London
- Kathleen L. Donahue
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Marco J. Nardin
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Adrian V. Dalca
- Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology
- Anne-Katrin Giese
- Department of Neurology, University Medical Center Hamburg‐Eppendorf
- Mark R. Etherton
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Brandon L. Hancock
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
- Steven J. T. Mocking
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
- Elissa C. McIntosh
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
- John Attia
- Hunter Medical Research Institute
- Oscar R. Benavente
- Department of Medicine, Division of Neurology, University of British Columbia
- Stephen Bevan
- School of Life Sciences, University of Lincoln
- John W. Cole
- Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System
- Amanda Donatti
- School of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)
- Christoph J. Griessenauer
- Department of Neurosurgery, Geisinger
- Laura Heitsch
- Department of Emergency Medicine, Washington University School of Medicine
- Lukas Holmegaard
- Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Katarina Jood
- Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Jordi Jimenez-Conde
- Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autonoma de Barcelona
- Steven J. Kittner
- Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System
- Robin Lemmens
- KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND)
- Christopher R. Levi
- School of Medicine and Public Health, University of Newcastle
- Caitrin W. McDonough
- Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida
- James F. Meschia
- Department of Neurology, Mayo Clinic
- Chia-Ling Phuah
- Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital
- Arndt Rolfs
- Centogene AG
- Stefan Ropele
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz
- Jonathan Rosand
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- Jaume Roquer
- Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autonoma de Barcelona
- Tatjana Rundek
- Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami
- Ralph L. Sacco
- Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami
- Reinhold Schmidt
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz
- Pankaj Sharma
- Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL)
- Agnieszka Slowik
- Department of Neurology, Jagiellonian University Medical College
- Martin Söderholm
- Department of clinical sciences Malmö, Lund University
- Alessandro Sousa
- School of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)
- Tara M. Stanne
- Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg
- Daniel Strbian
- Department of Neurology, Helsinki University Hospital and University of Helsinki
- Turgut Tatlisumak
- Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg
- Vincent Thijs
- Stroke Division, Florey Institute of Neuroscience and Mental Health
- Achala Vagal
- Department of Radiology, University of Cincinnati College of Medicine
- Johan Wasselius
- Department of Clinical Sciences Lund, Radiology, Lund University
- Daniel Woo
- Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine
- Ramin Zand
- Department of Neurology, Geisinger
- Patrick F. McArdle
- Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Bradford B. Worrall
- Departments of Neurology and Public Health Sciences, University of Virginia
- Christina Jern
- Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg
- Arne G. Lindgren
- Department of Neurology, Skåne University Hospital
- Jane Maguire
- University of Technology Sydney
- Danilo Bzdok
- Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University
- Ona Wu
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
- MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium
- Natalia S. Rost
- J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-23492-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Acute ischemic stroke impacts men and women differently. Here, the authors show how different lesion patterns in men and women are linked to the extent of stroke severity.
