Nature Communications (Nov 2021)

Optical deciphering of multinary chiral compound mixtures through organic reaction based chemometric chirality sensing

  • Diandra S. Hassan,
  • Christian Wolf

DOI
https://doi.org/10.1038/s41467-021-26874-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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The stereoselective analysis of mixtures of chiral compounds typically requires time-consuming chromatography. Here, the authors combine reaction based chiroptical sensing and chemometric tools to directly determine the absolute configuration, enantiomeric composition and concentration of convoluted samples without physical separation.