Vliyanie metformina na provospalitel'nyei prokoagulyantnye narusheniya u patsientokv postmenopauze s metabolicheskim sindromom

Abstract

The aim of the study was to assess the effect of metformin plus lifestyle modification on procoagulant and proinflammatory state associated with metabolic syndrome in postmenopausal women. Materials and methods: The 12-month prospective, open, randomized study included 58 postmenopausal women (age 55 [53; 56]; postmenopause 5 [4; 8] years) with metabolic syndrome (IDF, 2005). Participants were randomized into two groups receiving either metformin (1 g per day) plus lifestyle modification (n=29), or lifestyle modification alone (control group) (n=29). Blood tests were performed before and after the treatment period to evaluate parameters of coagulant and anticoagulant blood systems: prothrombin index, activated partial tromboplastin time (APTT), thrombin time, activities of factors VII (FVII),VIII (FVIII), von Willebrand factor (vWF), antithrombin III, plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (t-PA) and screening test for the protein C pathway. Also we assessed fibrinogen, C-reactive protein (CRP) and adiponectin concentrations. Results: After one year of treatment in metformin group CRP level decreased significantly from 4,98 [2,72; 11,95] to 2,56 [1,92; 6,76] mg/l (р

Keywords

• with metabolic syndrome. keywords: