Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer

Jing Zhang; Min Jiang; Chang-Sheng Wang; Kai Guo; Quan-Xin Li; Cheng Ma; Shao-Fei Ni; Gen-Qiang Chen; Yan Zong; Hua Lu; Li-Wen Xu; Xinxin Shao

doi:10.1038/s41467-022-35613-7

Nature Communications (Dec 2022)

Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer

Jing Zhang,
Min Jiang,
Chang-Sheng Wang,
Kai Guo,
Quan-Xin Li,
Cheng Ma,
Shao-Fei Ni,
Gen-Qiang Chen,
Yan Zong,
Hua Lu,
Li-Wen Xu,
Xinxin Shao

Affiliations

Jing Zhang: College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University
Min Jiang: College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University
Chang-Sheng Wang: College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University
Kai Guo: College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University
Quan-Xin Li: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guang-dong Province, Shantou University
Cheng Ma: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guang-dong Province, Shantou University
Shao-Fei Ni: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guang-dong Province, Shantou University
Gen-Qiang Chen: Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology
Yan Zong: Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology
Hua Lu: College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University
Li-Wen Xu: College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University
Xinxin Shao: College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University

DOI: https://doi.org/10.1038/s41467-022-35613-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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The pursuit of efficient C–N bond formation is a prime focus of synthetic organic chemistry. Here, the authors documented a base promoted amination between alkyl iodides and diazonium salts via halogen-atom transfer (XAT) process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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