Nature Communications (Oct 2022)
The N 6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity
- Masanori Yoshinaga,
- Kyuho Han,
- David W. Morgens,
- Takuro Horii,
- Ryosuke Kobayashi,
- Tatsuaki Tsuruyama,
- Fabian Hia,
- Shota Yasukura,
- Asako Kajiya,
- Ting Cai,
- Pedro H. C. Cruz,
- Alexis Vandenbon,
- Yutaka Suzuki,
- Yukio Kawahara,
- Izuho Hatada,
- Michael C. Bassik,
- Osamu Takeuchi
Affiliations
- Masanori Yoshinaga
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Kyuho Han
- Department of Genetics, Stanford University School of Medicine
- David W. Morgens
- Department of Genetics, Stanford University School of Medicine
- Takuro Horii
- Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
- Ryosuke Kobayashi
- Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
- Tatsuaki Tsuruyama
- Department of Drug and Discovery Medicine, Graduate School of Medicine, Kyoto University
- Fabian Hia
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Shota Yasukura
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Asako Kajiya
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Ting Cai
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Pedro H. C. Cruz
- Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University
- Alexis Vandenbon
- Laboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University
- Yutaka Suzuki
- Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Yukio Kawahara
- Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University
- Izuho Hatada
- Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
- Michael C. Bassik
- Department of Genetics, Stanford University School of Medicine
- Osamu Takeuchi
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-022-34078-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
In this work, Yoshinaga et al. use functional CRISPR screens and in vivo analyses to show that an RNA methyltransferase METTL16 and MTR4-nuclear exosome play an essential role in maintaining erythropoiesis and regulating DNA repair in erythroblasts.
