Journal of Neuroinflammation (Feb 2023)
Depletion and activation of microglia impact metabolic connectivity of the mouse brain
- Johannes Gnörich,
- Anika Reifschneider,
- Karin Wind,
- Artem Zatcepin,
- Sebastian T. Kunte,
- Philipp Beumers,
- Laura M. Bartos,
- Thomas Wiedemann,
- Maximilian Grosch,
- Xianyuan Xiang,
- Maryam K. Fard,
- Francois Ruch,
- Georg Werner,
- Mara Koehler,
- Luna Slemann,
- Selina Hummel,
- Nils Briel,
- Tanja Blume,
- Yuan Shi,
- Gloria Biechele,
- Leonie Beyer,
- Florian Eckenweber,
- Maximilian Scheifele,
- Peter Bartenstein,
- Nathalie L. Albert,
- Jochen Herms,
- Sabina Tahirovic,
- Christian Haass,
- Anja Capell,
- Sibylle Ziegler,
- Matthias Brendel
Affiliations
- Johannes Gnörich
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Anika Reifschneider
- Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München
- Karin Wind
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Artem Zatcepin
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Sebastian T. Kunte
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Philipp Beumers
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Laura M. Bartos
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Thomas Wiedemann
- Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München
- Maximilian Grosch
- German Center for Vertigo and Balance Disorders, University Hospital, Ludwig-Maximilians-Universität München
- Xianyuan Xiang
- Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München
- Maryam K. Fard
- German Center for Neurodegenerative Diseases (DZNE)
- Francois Ruch
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Georg Werner
- Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München
- Mara Koehler
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Luna Slemann
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Selina Hummel
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Nils Briel
- German Center for Neurodegenerative Diseases (DZNE)
- Tanja Blume
- German Center for Neurodegenerative Diseases (DZNE)
- Yuan Shi
- German Center for Neurodegenerative Diseases (DZNE)
- Gloria Biechele
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Leonie Beyer
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Florian Eckenweber
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Maximilian Scheifele
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Peter Bartenstein
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Nathalie L. Albert
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Jochen Herms
- German Center for Neurodegenerative Diseases (DZNE)
- Sabina Tahirovic
- German Center for Neurodegenerative Diseases (DZNE)
- Christian Haass
- German Center for Neurodegenerative Diseases (DZNE)
- Anja Capell
- Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München
- Sibylle Ziegler
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- Matthias Brendel
- Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München
- DOI
- https://doi.org/10.1186/s12974-023-02735-8
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 14
Abstract
Highlights Microglial activation influences metabolic connectivity. Microglial depletion results in distinct decreases of metabolic connectivity. Metabolic connectivity increases in progranulin deficient mice. Cellular FDG allocation in progranulin deficient mice is shifted to microglia.
Keywords
