Nature Communications (Nov 2018)

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

  • Sasirekha Ramani,
  • Christopher J. Stewart,
  • Daniel R. Laucirica,
  • Nadim J. Ajami,
  • Bianca Robertson,
  • Chloe A. Autran,
  • Dhairyasheel Shinge,
  • Sandya Rani,
  • Sasirekha Anandan,
  • Liya Hu,
  • Josephine C. Ferreon,
  • Kurien A. Kuruvilla,
  • Joseph F. Petrosino,
  • B. V. Venkataram Prasad,
  • Lars Bode,
  • Gagandeep Kang,
  • Mary K. Estes

DOI
https://doi.org/10.1038/s41467-018-07476-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Neonatal rotavirus infections are associated with gastrointestinal symptoms in some settings, but the role of host factors in clinical presentation is unclear. Here, Ramani et al. show that human milk oligosaccharides and microbiome are associated with symptomatic infection with neonatal strain G10P[11].