Revolutionizing prostate cancer diagnosis: Unleashing the potential of an optimized deep belief network for accurate Gleason grading in histological images

Abstract

PC (Prostate Cancer) is the second highest cause of death due to cancer in men globally. Proper detection and treatment are critical for halting or controlling the growth and spread of cancer cells within the human organism. However, evaluating these sorts of images is difficult and time-consuming, requiring histopathological image recognition as the most reliable method for treating PC because of its distinct visual characteristics. Risk evaluation and treatment planning rely heavily on histological image-based Gleason grading of prostate tumors. This work introduces an innovative approach to histological image analysis for prostate cancer diagnosis and Gleason grading. The Elephant Herding Optimization-based Hyper-parameter Convolutional Deep Belief Network (CDBN-EHO) is presented alongside a grading network head-optimized deep belief network technique for multi-task prediction. Leveraging an effective Bayesian inference method, fully linked Conditional Random Field (CRF) techniques are utilized for segmentation, with pairwise boundary capacities determined by a linear mixture of Gaussian kernels. The multi-task approach aims to enhance performance by incorporating contextual information, leading to breakthrough results in the identification of epithelial cells and the grading of Gleason scores. The objective of this study is to demonstrate the effectiveness of the optimized deep belief network technique in improving diagnostic accuracy and efficiency for prostate cancer diagnosis and Gleason grading in histological images.

Keywords

• Prostate cancer
• Gleason grading
• Histological images
• Elephant herding optimization
• Hyper-parameter and Gaussian kernels