Nature Communications (Feb 2022)
Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma
- Maximilian Merz,
- Almuth Maria Anni Merz,
- Jie Wang,
- Lei Wei,
- Qiang Hu,
- Nicholas Hutson,
- Cherie Rondeau,
- Kimberly Celotto,
- Ahmed Belal,
- Ronald Alberico,
- AnneMarie W. Block,
- Hemn Mohammadpour,
- Paul K. Wallace,
- Joseph Tario,
- Jesse Luce,
- Sean T. Glenn,
- Prashant Singh,
- Megan M. Herr,
- Theresa Hahn,
- Mehmet Samur,
- Nikhil Munshi,
- Song Liu,
- Philip L. McCarthy,
- Jens Hillengass
Affiliations
- Maximilian Merz
- Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park)
- Almuth Maria Anni Merz
- Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park)
- Jie Wang
- Department of Biostatistics and Bioinformatics, Roswell Park
- Lei Wei
- Department of Biostatistics and Bioinformatics, Roswell Park
- Qiang Hu
- Department of Biostatistics and Bioinformatics, Roswell Park
- Nicholas Hutson
- Department of Biostatistics and Bioinformatics, Roswell Park
- Cherie Rondeau
- Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park)
- Kimberly Celotto
- Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park)
- Ahmed Belal
- Department of Diagnostic Radiology, Roswell Park
- Ronald Alberico
- Department of Diagnostic Radiology, Roswell Park
- AnneMarie W. Block
- Clinical Cytogenetics Laboratory, Department of Pathology and Laboratory Medicine, Roswell Park
- Hemn Mohammadpour
- Department of Immunology, Roswell Park
- Paul K. Wallace
- Flow and Image Cytometry, Department of Pathology and Laboratory Medicine, Roswell Park
- Joseph Tario
- Flow and Image Cytometry, Department of Pathology and Laboratory Medicine, Roswell Park
- Jesse Luce
- Genomics Shared Resources, Roswell Park
- Sean T. Glenn
- Genomics Shared Resources, Roswell Park
- Prashant Singh
- Genomics Shared Resources, Roswell Park
- Megan M. Herr
- Transplant and Cellular Therapy Program, Department of Medicine, Roswell Park
- Theresa Hahn
- Transplant and Cellular Therapy Program, Department of Medicine, Roswell Park
- Mehmet Samur
- Department of Data Sciences, Dana Farber Cancer Institute
- Nikhil Munshi
- Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School
- Song Liu
- Department of Biostatistics and Bioinformatics, Roswell Park
- Philip L. McCarthy
- Transplant and Cellular Therapy Program, Department of Medicine, Roswell Park
- Jens Hillengass
- Department of Medicine, Roswell Park Comprehensive Cancer Center (Roswell Park)
- DOI
- https://doi.org/10.1038/s41467-022-28266-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Osteolytic lesions (OL) are frequent in multiple myeloma (MM), but are poorly understood. Here, the authors characterise OLs in MM patient samples using single-cell RNA-seq, revealing genes that are specifically regulated in OL compared to random bone marrow aspirates and that reflect the response to induction therapy.
