Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort

Abstract

Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 (IL-17) can facilitate the secretion of numerous proinflammatory cytokines. The goal of the present study was to evaluate the effect of IL-17F rs763780 on CLL/MM susceptibility in a Turkish cohort.Methods: The study included 37 patients with CLL, 21 patients with MM, and 100 healthy controls. The IL-17F rs763780 variant was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The frequencies of the alleles and genotypes in patient and control groups were compared by the χ2 test.Results: No significant difference was found in the distribution of genotypes and alleles frequencies for IL-17F rs 763780 between the patients and the healthy controls (P>0.05).Conclusion: Our results suggest that IL-17 rs763780 variant may not contribute to CLL and MM pathogenesis.

Keywords

• Chronic lymphocytic leukemia
• multiple myeloma
• interleukin-17F
• variant