Pharmacogenomics and Personalized Medicine (Sep 2021)
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma
Abstract
Li-Zhi Li, Zhuang-Zhuang Wu, Zhi Lv Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of ChinaCorrespondence: Li-Zhi LiDepartment of Orthopaedics, The Second Hospital of Shanxi Medical University, NO. 382 Wuyi Road, Taiyuan, 030001, People’s Republic of ChinaTel +86 351-3365105Email [email protected]: The present study aims to explore the correlation between osteosarcoma (OS) chemosensitivity and the expression levels of serum and tumor tissue micro-ribonucleic acid-21 (miR-21).Methods: The relevant miR-21 expression levels in 30 patients with OS were detected, and the gender, age, tumor location, pathological type, Enneking stage, and miR-21 expression changes before and after chemotherapy were retrospectively analyzed.Results: Serum and tumor tissue miR21 expression levels were significantly higher in patients with OS than in control subjects; the serum miR-21 expressions before and after chemotherapy were not related to patient age and gender. The effective chemotherapy group showed significant differences in miR-21 expression levels before and after chemotherapy.Conclusion: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS.Keywords: osteosarcoma, tumor tissue, serum, miR-21, chemotherapy
