Nature Communications (Jan 2020)
Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Abstract
Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.