ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

Abstract

Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm associated antigen 4) and NKX3-1 (NK3 homeobox 1) in U87MG glioblastoma cells in response to inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioblastoma growth.

Keywords

• u87mg glioblastoma cells
• ern1 knockdown
• hypoxia
• homeobox genes
• mrna expression