A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

Abstract

A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1), was isolated from the endophytic fungus Penicillium chermesinum. The structure was established on the basis of UV, IR, HR-ESI MS, and 1D and 2D NMR experiments. The cytotoxicity against four cancer cell lines (HuCCA-1, HepG2, A-549, and MOLT-3) of compound 1 are 14.94-115.71 µM.

Keywords

• Penicillium chermesinum
• natural products
• polyketide
• endophytic fungi
• cytotoxicity