Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
Victoriya Popova,
Yuliya Poletaeva,
Inna Pyshnaya,
Dmitrii Pyshnyi,
Elena Dmitrienko
Affiliations
Victoriya Popova
Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia
Yuliya Poletaeva
Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia
Inna Pyshnaya
Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia
Dmitrii Pyshnyi
Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia
Elena Dmitrienko
Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia
Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO3 (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: DOXorubicin (DOX). We also showed a prolonged pH-dependent release of DOX from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO3-and-DOX–based composite (CaNP7-DOX) in in vitro models.
