KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Jiong Li; Bo Yu; Peng Deng; Yingduan Cheng; Yongxin Yu; Kareena Kevork; Sivakumar Ramadoss; Xiangming Ding; Xinmin Li; Cun-Yu Wang

doi:10.1038/ncomms15146

Nature Communications (Apr 2017)

KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Jiong Li,
Bo Yu,
Peng Deng,
Yingduan Cheng,
Yongxin Yu,
Kareena Kevork,
Sivakumar Ramadoss,
Xiangming Ding,
Xinmin Li,
Cun-Yu Wang

Affiliations

Jiong Li: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Bo Yu: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Peng Deng: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Yingduan Cheng: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Yongxin Yu: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Kareena Kevork: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Sivakumar Ramadoss: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA
Xiangming Ding: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA
Xinmin Li: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA
Cun-Yu Wang: Division of Oral Biology and Medicine, Laboratory of Molecular Signaling, School of Dentistry and Broad Stem Cell Research Center, UCLA

DOI: https://doi.org/10.1038/ncomms15146
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 methylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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