Effect of Green Tea on Development of Atherosclerogenic Lesions Induced by Experimentally Hydrogen Peroxide in Female Rat Experimental

Abstract

This study was conducted to investigate the ability of green tea as antioxidant and antiatherogenic in female rats after treated with 0.5o/o of H20 2 in order to induced atherosclerosis. The results showed capability of H20 2 0.5% to initiate of oxidative stress via significant increase in tissue MDA in aorta and heart associated with decrease in GSH, as well as, increase in ijDL-c and decrease in LDL-c in serum of treated rats. Histologically, aorta and heart sections revealed less improvement in histological picture, reduction lipid vacuoles in both intimal and medial layers associated with proliferation of vascular smooth muscle cells but it not reach to normal tissue.

Keywords

• green tea
• atherosclerogenic lesions
• female rat