Nature Communications (Sep 2017)

Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides

  • Guangyan Qing,
  • Qi Lu,
  • Xiuling Li,
  • Jing Liu,
  • Mingliang Ye,
  • Xinmiao Liang,
  • Taolei Sun

DOI
https://doi.org/10.1038/s41467-017-00464-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.