A Myb enhancer-guided analysis of basophil and mast cell differentiation

Takayoshi Matsumura; Haruhito Totani; Yoshitaka Gunji; Masahiro Fukuda; Rui Yokomori; Jianwen Deng; Malini Rethnam; Chong Yang; Tze King Tan; Tadayoshi Karasawa; Kazuomi Kario; Masafumi Takahashi; Motomi Osato; Takaomi Sanda; Toshio Suda

doi:10.1038/s41467-022-34906-1

Nature Communications (Nov 2022)

A Myb enhancer-guided analysis of basophil and mast cell differentiation

Takayoshi Matsumura,
Haruhito Totani,
Yoshitaka Gunji,
Masahiro Fukuda,
Rui Yokomori,
Jianwen Deng,
Malini Rethnam,
Chong Yang,
Tze King Tan,
Tadayoshi Karasawa,
Kazuomi Kario,
Masafumi Takahashi,
Motomi Osato,
Takaomi Sanda,
Toshio Suda

Affiliations

Takayoshi Matsumura: Cancer Science Institute of Singapore, National University of Singapore
Haruhito Totani: Cancer Science Institute of Singapore, National University of Singapore
Yoshitaka Gunji: Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University
Masahiro Fukuda: Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School
Rui Yokomori: Cancer Science Institute of Singapore, National University of Singapore
Jianwen Deng: Cancer Science Institute of Singapore, National University of Singapore
Malini Rethnam: Cancer Science Institute of Singapore, National University of Singapore
Chong Yang: Cancer Science Institute of Singapore, National University of Singapore
Tze King Tan: Cancer Science Institute of Singapore, National University of Singapore
Tadayoshi Karasawa: Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University
Kazuomi Kario: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
Masafumi Takahashi: Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University
Motomi Osato: Cancer Science Institute of Singapore, National University of Singapore
Takaomi Sanda: Cancer Science Institute of Singapore, National University of Singapore
Toshio Suda: Cancer Science Institute of Singapore, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-34906-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The transcription factor MYB has been shown to regulate haematopoietic stem cells but there could be lineage specific enhancers. Here, using lineage tracing and single cell sequencing the authors characterise a Myb −68 enhancer that regulates the differentiation of mast cells and basophils.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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