Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum

Hisako Nakayama; Manabu Abe; Chie Morimoto; Tadatsune Iida; Shigeo Okabe; Kenji Sakimura; Kouichi Hashimoto

doi:10.1038/s41467-018-05100-z

Nature Communications (Jul 2018)

Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum

Hisako Nakayama,
Manabu Abe,
Chie Morimoto,
Tadatsune Iida,
Shigeo Okabe,
Kenji Sakimura,
Kouichi Hashimoto

Affiliations

Hisako Nakayama: Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University
Manabu Abe: Department of Cellular Neurobiology, Brain Research Institute, Niigata University
Chie Morimoto: Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University
Tadatsune Iida: Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo
Shigeo Okabe: Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo
Kenji Sakimura: Department of Cellular Neurobiology, Brain Research Institute, Niigata University
Kouichi Hashimoto: Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University

DOI: https://doi.org/10.1038/s41467-018-05100-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of GABAergic inhibition prerequisite for pruning.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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