Nature Communications (Aug 2020)
Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
Abstract
Substantial efforts have been devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. This work describes a copper-catalyzed asymmetric synthesis of exocyclic allenes by simultaneous control of axial and central chirality.