Nature Communications (Aug 2020)

Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes

  • Cheng-Yu He,
  • Yun-Xuan Tan,
  • Xin Wang,
  • Rui Ding,
  • Yi-Fan Wang,
  • Feng Wang,
  • Dingding Gao,
  • Ping Tian,
  • Guo-Qiang Lin

DOI
https://doi.org/10.1038/s41467-020-18136-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

Substantial efforts have been devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. This work describes a copper-catalyzed asymmetric synthesis of exocyclic allenes by simultaneous control of axial and central chirality.