Nature Communications (Sep 2017)
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
- Svitlana Tyekucheva,
- Michaela Bowden,
- Clyde Bango,
- Francesca Giunchi,
- Ying Huang,
- Chensheng Zhou,
- Arrigo Bondi,
- Rosina Lis,
- Mieke Van Hemelrijck,
- Ove Andrén,
- Sven-Olof Andersson,
- R. William Watson,
- Stephen Pennington,
- Stephen P. Finn,
- Neil E. Martin,
- Meir J. Stampfer,
- Giovanni Parmigiani,
- Kathryn L. Penney,
- Michelangelo Fiorentino,
- Lorelei A. Mucci,
- Massimo Loda
Affiliations
- Svitlana Tyekucheva
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
- Michaela Bowden
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Clyde Bango
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Francesca Giunchi
- Department of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna
- Ying Huang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Chensheng Zhou
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Arrigo Bondi
- Department of Surgical Pathology, Maggiore Hospital
- Rosina Lis
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Mieke Van Hemelrijck
- King’s College London, Division of Cancer Studies, Translational Oncology & Urology Research, Guy’s Hospital
- Ove Andrén
- Department of Urology, School of Health and Medical Sciences, Örebro University Hospital
- Sven-Olof Andersson
- Department of Urology, School of Health and Medical Sciences, Örebro University Hospital
- R. William Watson
- School of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin
- Stephen Pennington
- School of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin
- Stephen P. Finn
- Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin
- Neil E. Martin
- Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School
- Meir J. Stampfer
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Giovanni Parmigiani
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
- Kathryn L. Penney
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Michelangelo Fiorentino
- Department of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna
- Lorelei A. Mucci
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Massimo Loda
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-017-00460-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.
