Nature Communications (May 2017)
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
- Lam C. Tsoi,
- Philip E. Stuart,
- Chao Tian,
- Johann E. Gudjonsson,
- Sayantan Das,
- Matthew Zawistowski,
- Eva Ellinghaus,
- Jonathan N. Barker,
- Vinod Chandran,
- Nick Dand,
- Kristina Callis Duffin,
- Charlotta Enerbäck,
- Tõnu Esko,
- Andre Franke,
- Dafna D. Gladman,
- Per Hoffmann,
- Külli Kingo,
- Sulev Kõks,
- Gerald G. Krueger,
- Henry W. Lim,
- Andres Metspalu,
- Ulrich Mrowietz,
- Sören Mucha,
- Proton Rahman,
- Andre Reis,
- Trilokraj Tejasvi,
- Richard Trembath,
- John J. Voorhees,
- Stephan Weidinger,
- Michael Weichenthal,
- Xiaoquan Wen,
- Nicholas Eriksson,
- Hyun M. Kang,
- David A. Hinds,
- Rajan P. Nair,
- Gonçalo R. Abecasis,
- James T Elder
Affiliations
- Lam C. Tsoi
- Department of Dermatology, University of Michigan Medical School
- Philip E. Stuart
- Department of Dermatology, University of Michigan Medical School
- Chao Tian
- 23andMe, Inc., Mountain View
- Johann E. Gudjonsson
- Department of Dermatology, University of Michigan Medical School
- Sayantan Das
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Matthew Zawistowski
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Eva Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Jonathan N. Barker
- Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London
- Vinod Chandran
- Department of Medicine, Division of Rheumatology, University of Toronto
- Nick Dand
- Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London
- Kristina Callis Duffin
- Department of Dermatology, University of Utah
- Charlotta Enerbäck
- Department of Dermatology, Linköping University
- Tõnu Esko
- Estonian Genome Center, University of Tartu
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Dafna D. Gladman
- Department of Medicine, Division of Rheumatology, University of Toronto
- Per Hoffmann
- Institute of Human Genetics, University of Bonn
- Külli Kingo
- Department of Dermatology and Venereology, Dermatology Clinic, Tartu University Hospital, University of Tartu
- Sulev Kõks
- Department of Pathophysiology, Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu
- Gerald G. Krueger
- Department of Dermatology, University of Utah
- Henry W. Lim
- Department of Dermatology, Henry Ford Hospital
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Ulrich Mrowietz
- Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel
- Sören Mucha
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Proton Rahman
- Memorial University, St. John's
- Andre Reis
- Institute of Human Genetics, FAU Erlangen-Nürnberg
- Trilokraj Tejasvi
- Department of Dermatology, University of Michigan Medical School
- Richard Trembath
- Department of Medical and Molecular Genetics, King’s College London
- John J. Voorhees
- Department of Dermatology, University of Michigan Medical School
- Stephan Weidinger
- Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel
- Michael Weichenthal
- Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel
- Xiaoquan Wen
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Nicholas Eriksson
- 23andMe, Inc., Mountain View
- Hyun M. Kang
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- David A. Hinds
- 23andMe, Inc., Mountain View
- Rajan P. Nair
- Department of Dermatology, University of Michigan Medical School
- Gonçalo R. Abecasis
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- James T Elder
- Department of Dermatology, University of Michigan Medical School
- DOI
- https://doi.org/10.1038/ncomms15382
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
