Journal of Nanobiotechnology (Nov 2023)

Plant-derived nanovesicles: harnessing nature's power for tissue protection and repair

  • Xiaohang Chen,
  • Xiaojie Xing,
  • Shuoqi Lin,
  • Liyu Huang,
  • Lianghang He,
  • Yuchun Zou,
  • Xuyang Zhang,
  • Bohua Su,
  • Youguang Lu,
  • Dali Zheng

DOI
https://doi.org/10.1186/s12951-023-02193-7
Journal volume & issue
Vol. 21, no. 1
pp. 1 – 30

Abstract

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Abstract Tissue damage and aging lead to dysfunction, disfigurement, and trauma, posing significant global challenges. Creating a regenerative microenvironment to resist external stimuli and induce stem cell differentiation is essential. Plant-derived nanovesicles (PDNVs) are naturally bioactive lipid bilayer nanovesicles that contain proteins, lipids, ribonucleic acid, and metabolites. They have shown potential in promoting cell growth, migration, and differentiation into various types of tissues. With immunomodulatory, microbiota regulatory, antioxidant, and anti-aging bioactivities, PDNVs are valuable in resisting external stimuli and facilitating tissue repair. The unique structure of PDNVs provides an optimal platform for drug encapsulation, and surface modifications enhance their stability and specificity. Moreover, by employing synergistic administration strategies, PDNVs can maximize their therapeutic potential. This review summarized the progress and prospects of PDNVs as regenerative tools, provided insights into their selection for repair activities based on existing studies, considered the key challenge for clinical application, and anticipated their continued prominent role in the field of biomedicine. Graphical Abstract