Frontiers in Molecular Neuroscience (Sep 2017)
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro
- Feng-Juan Gao,
- Sheng-Hai Zhang,
- Sheng-Hai Zhang,
- Sheng-Hai Zhang,
- Sheng-Hai Zhang,
- Ping Xu,
- Ping Xu,
- Ping Xu,
- Ping Xu,
- Bo-Qi Yang,
- Bo-Qi Yang,
- Bo-Qi Yang,
- Bo-Qi Yang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Yun Cheng,
- Yun Cheng,
- Yun Cheng,
- Yun Cheng,
- Xu-Jiao Zhou,
- Xu-Jiao Zhou,
- Xu-Jiao Zhou,
- Xu-Jiao Zhou,
- Wan-Jing Huang,
- Min Wang,
- Jun-Yi Chen,
- Xing-Huai Sun,
- Xing-Huai Sun,
- Xing-Huai Sun,
- Xing-Huai Sun,
- Ji-Hong Wu,
- Ji-Hong Wu,
- Ji-Hong Wu,
- Ji-Hong Wu
Affiliations
- Feng-Juan Gao
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Sheng-Hai Zhang
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Sheng-Hai Zhang
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Sheng-Hai Zhang
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Sheng-Hai Zhang
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Ping Xu
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Ping Xu
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Ping Xu
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Ping Xu
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Bo-Qi Yang
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Bo-Qi Yang
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Bo-Qi Yang
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Bo-Qi Yang
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Rong Zhang
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Rong Zhang
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Rong Zhang
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Rong Zhang
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Yun Cheng
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Yun Cheng
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Yun Cheng
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Yun Cheng
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Xu-Jiao Zhou
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Xu-Jiao Zhou
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Xu-Jiao Zhou
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Xu-Jiao Zhou
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Wan-Jing Huang
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Min Wang
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Jun-Yi Chen
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Xing-Huai Sun
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Xing-Huai Sun
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Xing-Huai Sun
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Xing-Huai Sun
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- Ji-Hong Wu
- Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, China
- Ji-Hong Wu
- State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, China
- Ji-Hong Wu
- Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, China
- Ji-Hong Wu
- Key Laboratory of Myopia, Ministry of HealthShanghai, China
- DOI
- https://doi.org/10.3389/fnmol.2017.00285
- Journal volume & issue
-
Vol. 10
Abstract
Glaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, widely distributed in fruits and vegetables. Mounting evidence suggests that Qcn has numerous neuroprotective effects. However, whether Qcn exerts neuroprotective effects on RGC in glaucoma is poorly understood. In this study, we investigated the protective effect of Qcn against RGC damage in a rat chronic ocular hypertension (COHT) model invivo and hypoxia-induced primary cultured RGC damage in vitro, and we further explored the underlying neuroprotective mechanisms. We found that Qcn not only improved RGC survival and function from a very early stage of COHT invivo, it promoted the survival of hypoxia-treated primary cultured RGCs invitro via ameliorating mitochondrial function and preventing mitochondria-mediated apoptosis. Our findings suggest that Qcn has direct protective effects on RGCs that are independent of lowering the intraocular pressure (IOP). Qcn may be a promising therapeutic agent for improving RGC survival and function in glaucomatous neurodegeneration.
Keywords
