Approach to acute valproic acid intoxication: A case presentation

Abstract

Valproic acid (VA) is a broad spectrum antiepileptic that is commonly used in epilepsy, mood disorders and migraine prophylaxis. Although it is not encountered frequently, VAintoxication can be seen during childhood. In VAintoxication, mainly the central nervous system and also liver, heart, kidneys, lungs and hematological system are affected. Since acute VA intoxication can lead to serious complications, and also it may be fatal; the clinical and laboratory follow-up together with early treatment are essential. In this case presentation, we aimed to examine the approach to acute VA intoxication in a case that occurred after ingestion of high dose ofVA for suicidal purpose.

Keywords

• valproic acid
• intoxication
• mortality
• management
• l-carnitine