Advanced Nanomedicine Approaches for Myocardial Infarction Treatment

Abstract

Lin Song, Kangwei Jia, Fuqing Yang, Jianxun Wang School of Basic Medicine, Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Jianxun Wang, School of Basic Medicine, Qingdao University, Qingdao, People’s Republic of China, Tel [phone], Email [email protected]: Myocardial infarction, usually caused by the rupture of atherosclerotic plaque, leads to irreversible ischemic cardiomyocyte death within hours followed by impaired cardiac performance or even heart failure. Current interventional reperfusion strategies for myocardial infarction still face high mortality with the development of heart failure. Nanomaterial-based therapy has made great progress in reducing infarct size and promoting cardiac repair after MI, although most studies are preclinical trials. This review focuses primarily on recent progress (2016–now) in the development of various nanomedicines in the treatment of myocardial infarction. We summarize these applications with the strategy of mechanism including anti-cardiomyocyte death strategy, activation of neovascularization, antioxidants strategy, immunomodulation, anti-cardiac remodeling, and cardiac repair.Keywords: myocardial infarction, nanomaterials, nanomedicine delivery system

Keywords

• myocardial infarction
• nanomaterials
• nanomedicine delivery system;